Deep Learning for Multiclass Classification, Predictive Modeling and Segmentation of Disease Prone Regions in Alzheimer’s Disease

One of the challenges facing accurate diagnosis and prognosis of Alzheimer’s Disease (AD) is identifying the subtle changes that define the early onset of the disease. This dissertation investigates three of the main challenges confronted when such subtle changes are to be identified in the most meaningful way. These are (1) the missing data challenge, (2) longitudinal modeling of disease progression, and (3) the segmentation and volumetric calculation of disease-prone brain areas in medical images. The scarcity of sufficient data compounded by the missing data challenge in many longitudinal samples exacerbates the problem as we seek statistical meaningfulness in multiclass classification and regression analysis. Although there are many participants in the AD Neuroimaging Initiative (ADNI) study, many of the observations have a lot of missing features which often lead to the exclusion of potentially valuable data points that could add significant meaning in many ongoing experiments. Motivated by the necessity of examining all participants, even those with missing tests or imaging modalities, multiple techniques of handling missing data in this domain have been explored. Specific attention was drawn to the Gradient Boosting (GB) algorithm which has an inherent capability of addressing missing values. Prior to applying state-of-the-art classifiers such as Support Vector Machine (SVM) and Random Forest (RF), the impact of imputing data in common datasets with numerical techniques has been also investigated and compared with the GB algorithm. Furthermore, to discriminate AD subjects from healthy control individuals, and Mild Cognitive Impairment (MCI), longitudinal multimodal heterogeneous data was modeled using recurring neural networks (RNNs). In the segmentation and volumetric calculation challenge, this dissertation places its focus on one of the most relevant disease-prone areas in many neurological and neurodegenerative diseases, the hippocampus region. Changes in hippocampus shape and volume are considered significant biomarkers for AD diagnosis and prognosis. Thus, a two-stage model based on integrating the Vision Transformer and Convolutional Neural Network (CNN) is developed to automatically locate, segment, and estimate the hippocampus volume from the brain 3D MRI. The proposed architecture was trained and tested on a dataset containing 195 brain MRIs from the 2019 Medical Segmentation Decathlon Challenge against the manually segmented regions provided therein and was deployed on 326 MRI from our own data collected through Mount Sinai Medical Center as part of the 1Florida Alzheimer Disease Research Center (ADRC)

Online power quality disturbance detection by support vector machine in smart meter

Power quality assessment is an important performance measurement in smart grids. Utility companies are interested in power quality monitoring even in the low level distribution side such as smart meters. Addressing this issue, in this study, we propose segregation of the power disturbance from regular values using one-class support vector machine (OCSVM). To precisely detect the power disturbances of a voltage wave, some practical wavelet filters are applied. Considering the unlimited types of waveform abnormalities, OCSVM is picked as a semi-supervised machine learning algorithm which needs to be trained solely on a relatively large sample of normal data. This model is able to automatically detect the existence of any types of disturbances in real time, even unknown types which are not available in the training time. In the case of existence, the disturbances are further classified into different types such as sag, swell, transients and unbalanced. Being light weighted and fast, the proposed technique can be integrated into smart grid devices such as smart meter in order to perform a real-time disturbance monitoring. The continuous monitoring of power quality in smart meters will give helpful insight for quality power transmission and management

Mining Big Neuron Morphological Data

The advent of automatic tracing and reconstruction technology has led to a surge in the number of neurons 3D reconstruction data and consequently the neuromorphology research. However, the lack of machine-driven annotation schema to automatically detect the types of the neurons based on their morphology still hinders the development of this branch of science. Neuromorphology is important because of the interplay between the shape and functionality of neurons and the far-reaching impact on the diagnostics and therapeutics in neurological disorders. This survey paper provides a comprehensive research in the field of automatic neurons classification and presents the existing challenges, methods, tools, and future directions for automatic neuromorphology analytics. We summarize the major automatic techniques applicable in the field and propose a systematic data processing pipeline for automatic neuron classification, covering data capturing, preprocessing, analyzing, classification, and retrieval. Various techniques and algorithms in machine learning are illustrated and compared to the same dataset to facilitate ongoing research in the field